Ty and Abby Archer are a teenage brother-and-sister crime-fighting team who report to the Bureau of Grossology, a secret government agency whose job is to investigate gross criminals, their gross crimes, and/or various gross phenomena. Each episode of the series follows the pair on adventures based on real scientific facts. Aided by their friend Lab Rat (a tech specialist and a lab researcher), their boss The Director, and their police liaison, The Detective, Ty and Abby work to keep the city safe, all while keeping their identities hidden.