In the early 22nd Century, mankind has achieved two great scientific feats: one, the creation of the exo-frame, a highly capable machine piloted by humans for work in extreme conditions including outer space, enabling the terraforming of Mars and Venus. Two, the neo-sapien race, a genetically perfect species created solely for labor. Angered by their subhuman standing in mankind's empire, they were led to uprise by Phaeton. The militarized neo-sapiens soon overthrew humanity's hold on Earth and Mars, with their superior strength and intelligence. Now, cloning experiments are allowing them the possiblity to procreate and further their own species. Allying with the mercenary space pirate clans that litter the outer colonies, the ExoFleet is poising to retake the solar system and set humanity on a course for peace. Exo-Squad follows this overarching story, as well as the trials of Lt. J.T. Marsh and his squadron of pilots.